研究成果： |
课题组以小鼠为模式动物，综合利用细胞及分子生化实验技术，结合行为学测试，高通量测序技术手段研究大脑皮层发育的调控机制、神经精神疾病以及代谢类疾病神经发育缺陷的致病机制研究，先后于J. Neuroscience，Cell reports等知名杂志发表论文10余篇，主持国家自然科学基金青年基金 1 项；主持博士后科学基金面上项目一等资助1项。 代表性论文： 1. Yinghao Liu#, Min Wang#, Ye Guo#, Lei Wang, Weixiang Guo*. D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase. Cell Reports, 2023 Jan 31;42(2):112067. Q1 2. Ye Guo#, Xing Luo#, Weixiang Guo*. The impact of amino acid metabolism on adult neurogenesis. Biochemical Society Transactions, 2023 Feb 27;51(1):233-244. Q2 3. Ye Guo, Junjie Wu, Min Wang, Xin Wang, Youli Jian, Chonglin Yang, Weixiang Guo*. The metabolite saccharopine impairs neuronal development by inhibiting the neurotrophic function of glucose-6-phosphate isomerase. Journal of Neuroscience, 2022, 42(13): 2631-2646. (Featured Research) Q1 4. Yuhan Wang#, Ye Guo#, Changyong Tang#, Xiu Han, Mingyue Xu, Jing Sun, Yifei Zhao, Yiwen Zhang, Min Wang, Xiaofeng Cao, Xiaojuan Zhu and Weixiang Guo* (2019). Developmental Cytoplasmic-to Nuclear Translocation of RNA-Binding Protein HuR is Required for adult Neurogenesis. Cell Reports, 29: 3101-3117. Q1 5. Ye Guo#, Xu Chen#, Ruxiao Xing, Min Wang, Xiaojuan Zhu* and Weixiang Guo*(2018). Interplay Between FMRP and lncRNA TUG1 Regulates Axonal Development through Mediating SnoN-Ccd1 Pathway. Human Molecular Genetics, 27:475-485. Q2 6. Ye Guo, Xiaoxiao He, Lu Zhao, Lin Liu, Huifang Song, Xudong Wang, Jiahui Xu, Xingda Ju, Weixiang Guo* and Xiaojuan Zhu* (2017). Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex. Cerebral Cortex, 27:3414-3426. Q1 7. Mingming Lai#, Ye Guo#, Jun Ma, Huali Yu, Dongdong Zhao, Wenqiang Fan, Xingda Ju, Muhammad A. Sheikh, Yousra S. Malik, Wencheng Xiong, Weixiang Guo* and Xiaojuan Zhu* (2015). Myosin X regulates neuronal radial migration through interacting with n-cadherin. Frontiers in Cellular Neuroscience, 9, 326. Q2 带“#”标注为共同第一作者。 |
