报告题目：Bring the Power of Antibodies to the Bone
报告人：肖汉副教授（Rice University）
报告地点：新葡的京集团8814唐敖庆楼C区5楼会议室
报告时间：2023年9月1日9：00-11：00
主办单位：新葡的京集团8814
报告人简介：
肖汉，莱斯大学化学与生物科学系副教授。2010年本科毕业于中国科学技术大学， 之后进入 Scripps Research Institute (TSRI)攻读博士学位。2015 年加入斯坦福大学Carolyn R. Bertozzi 教授实验室做博士后，主要从事以细胞表面糖类免疫调节轴为靶点的新型癌症免疫疗法的开发。2018年入职莱斯大学化学与生物科学系，目前他的研究重点是开发各种化学生物工具，深入解读复杂的生物系统，并开发新的治疗策略。研究领域涵盖了合成化学、化学生物学、分子生物学、癌症生物学和免疫学等多个学科，研究成果发表在JACS, Chemical Science, Nature Communications, Protein Science, mBio, Plos Pathogens等权威杂志上。
报告内容：
Over the past 30 years, antibody-based therapies against cancer have been developed and proved to be successful in the clinic. Despite their clinical success, delivery of these antibodies to the bone niche has proven to be difficult due to relatively low vascularization and the physical barriers of penetration. Inspired by the bone-targeting mechanism of natural biomolecules, we have developed an innovative bone targeting (BonTarg) technology that enables the preparation of antibodies with both antigen and bone specificity. The resulting bone-targeting antibodies exhibit improved in vivo therapeutic efficacy in the treatment of breast cancer micrometastasis and in the prevention of secondary metastatic dissemination from the initial bone lesions. This study establishes a new strategy for transitioning antibody-based therapies from antigen-specific to both antigen and tissue-specific, thus providing a promising new avenue for advancing antibody therapy toward clinical translation.
