| 研究成果： |
研究工作主要由3部分组成：脱氧核酶酶学研究；基于脱氧核酶设计构建生物传感器（DNA分子探针）；利用分子定向进化技术筛选变构脱氧核酶。
代表性论文： (1) Yu, Wenqian; Wang, Shijin; Cao, Dongling; Rui, Hongyue; Liu, Chengcheng; Sheng, Yongjie; Sun, Yanhong; Zhang, Jin; Xu, Jiacui*; Jiang, Dazhi*; Insight into an oxidative DNA-cleaving DNAzyme: multiple cofactors, the catalytic core map and a highly efficient variant. iScience, 2020, 23(10): 101555. (2) Cao, Dongling; Yu, Wenqian; Xu, Jiacui; Wang, Fulong; Jiang, Ying; Sheng, Yongjie; Sun, Yanhong; Zhang, Jin; Jiang, Dazhi*; Characterization of a DNA-hydrolyzing DNAzyme for generation of PCR strands of unequal length. Biochimie, 2020, 179: 181-189. (3) Sun, Yanhong; Ma, Rulong; Wang, Shijin; Li, Guiying; Sheng, Yongjie; Rui, Hongyue; Zhang, Jin; Xu, Jiacui*; Jiang, Dazhi*; New cofactors and inhibitors for a DNA-cleaving DNAzyme: superoxide anion and hydrogen peroxide mediated an oxidative cleavage process. Scientific Reports, 2017, 7(1): 378. (4) Wang, Shijin; Liu, Chengcheng; Li, Guiying; Sheng, Yongjie; Sun, Yanhong; Rui, Hongyue; Zhang, Jin; Xu, Jiacui*; Jiang, Dazhi*; The triple roles of glutathione for a DNA-cleaving DNAzyme and development of a fluorescent glutathione/Cu2+-dependent DNAzyme sensor for detection of Cu2+ in drinking water. ACS Sensors, 2017, 2(3): 364-370. (5) Liu, Chengcheng; Sheng, Yongjie; Sun, Yanhong; Feng, Junkui; Wang, Shijin; Zhang, Jin*; Xu, Jiacui*; Jiang, Dazhi*; A glucose oxidase-coupled DNAzyme sensor for glucose detection in tears and saliva. Biosensors & Bioelectronics, 2015, 70: 455-461. |
