王磊 博士生导师
职称：教授
最高学位：博士
电话：13943085518
Email：w_lei@jlu.edu.cn
工作地点：生命科学楼279
微信公众号：JLU酶促有机合成
研究方向：1、酶促绿色有机合成
2、酶分子改造以及定向进化
3、生物医用材料合成及应用
教育经历：1997-2001：新葡的京集团8814大学化学学院化学专业，获理学学士学位
2001-2006：新葡的京集团8814化学学院有机化学系，获理学博士学位
工作经历：2006 -2008：新葡的京集团8814分子酶学工程教育部重点实验室担任讲师
2008-2014：新葡的京集团8814分子酶学工程教育部重点实验室任副教授
2014-现在：新葡的京集团8814分子酶学工程教育部重点实验室任教授
2012-2013：美国阿克伦大学化学系，访问学者
研究成果：
(1) Yaning Xu, Nan Zhao, Fengxi Li, Chunyu Wang, Hanqing Xie, Junhao Wu, Lei Cheng, Lei Wang*, Zhi Wang*, Application of Vitreoscilla hemoglobin as a green and efficient biocatalyst for the synthesis of benzoxazoles in water, ChemBioChem, 2024, 25(1), e202300609.
(2) Yong Tang, Kaifu Zhang, Yuelin Xu, Jinglin Ma, Hanqing Xie, Hongquan Zhang, Yanmin jiang, Rui Zhao*, Lei Wang*, Lipase-Catalyzed One-Pot Four-Component Reaction in Aqueous Media: Green Construction of Substituted 2,3-Dihydrothiophenes, New Journal of Chemistry, 2023, 47, 20316-20321.
(3) Fengxi Li, Yaning Xu, Yuelin Xu, Jinglin Ma, Hanqing Xie, Chunyu Wang, Zhengqiang Li*, Lei Wang*, Novel Dual-Enzyme System for Synthesis of 2-Alkyl and 2-Arylbenzoxazoles via Aer1obic Oxidation in Water, Org. Chem. Front., 2023, 10, 3509-3514.
(4) Fengxi Li, Yaning Xu, Yuelin Xu, Hanqing Xie, Junhao Wu, Chunyu Wang, Zhengqiang Li*, Lei Wang*, Engineering of Dual-Function Vitreoscilla Hemoglobin: An Efficient and One-Pot Strategy for the Synthesis of Unnatural α-Amino Acids, Organic Letters, 2023, 25(39), 7115-7119.
(5) Fengxi Li, Jinglin Ma, Hanqing Xie, Chunyu Wang, Zhengqiang Li, Chuang Du, Zhi Wang*, Lei Wang*, Highly Selective Hemin-Catalyzed Three-Component Aminoselenation and Oxyselenation of Alkenes, J. Organometal. Chem., 2023, 1001, 122866.
(6) Hanqing Xie, Fengxi Li, Yaning Xu, Chunyu Wang, Yuelin Xu, Junhao Wu, Zhengqiang Li*, Zhi Wang*，Lei Wang*, Vitreoscilla hemoglobin: A natural carbene transfer catalyst for diastereo- and enantioselective synthesis of nitrile-substituted cyclopropanes, Green Chemistry, 2023, 25, 6853-6858.
(7) Jinglin Ma#, Fengxi Li#, Chunyu Wang, Zhi Wang*, Chuang Du*, Lei Wang*, Synthesis of Isothiocyanates from Primary Amines via Visible-Light Photocatalysis, Org. Lett., 2023, 25, 5692-5696.
(8) Fengxi Li, Yaning Xu, Ciduo Wang, Chunyu Wang, Hanqing Xie, Yuelin Xu, Peng Chen*, Lei Wang*, An efficient synthesis of substituted pyrazoles via a [3+2] cycloaddition reaction catalyzed by lipase in ionic liquid, Process Biochem., 2023, 124, 253-258.
(9) Yuelin Xu, Fengxi Li, Yong Tang, Junhao Wu, Chunyu Wang, Chuang Du*, Zhi Wang*, Lei Wang*, Synthesis of functionalized 1,4-dihydropyridines containing benzosultams catalyzed by lipase, New Journal of Chemistry, 2023, 47, 9708-9713.
(10) Yue Yu, Fengxi Li, Xin Zheng, Haochen Tian, Zulpiya Mahmut, Tianyu Xiao, Yanan Du, Yuyin Dai*, Lei Wang*, Lipase-catalyzed hydrazine insertion for the synthesis of N’-alkyl benzohydrazides, Biotechnol. Appl. Biochem., 2023, 70, 130-136.
(11) Fengxi Li, Yaning Xu, Yuelin Xu, Chunyu Wang, Jinglin Ma, Peng Chen*, Lei Wang*, Hemin-catalyzed controlled oxidative cyanation of secondary amine for the synthesis of α-aminonitriles and α-iminonitriles, Molecular Catalysis, 2022, 529, 112576.
(12) Yaning Xu, Nan Zhao, Fengxi Li, Hanqing Xie, Yuelin Xu, Junhao Wu, Chunyu Wang, Zhengqiang Li* and Lei Wang*, Efficient and mild synthesis of 2-aryl benzothiazoles mediated by Vitreoscilla hemoglobin, Molecular Catalysis, 2022, 533, 112784.
(13) Jiapeng Li, Yue Yu, Yaning Xu, Fengxi Li, Yuqi Liu, Yifei Sun, Chunyu Wang, Peng Chen*, Lei Wang*, An efficient synthesis of 3-hydroxy chromones via oxidative cyclization mediated by lipase, Green Chemistry Letters and Reviews, 2022, 15(3), 689-694.
(14) Yaning Xu, Fengxi Li, Nan Zhao, Jiali Su, Chunyu Wang, Ciduo Wang, Zhengqiang Li* and Lei Wang*, Environment-friendly and efficient synthesis of 2-aminobenzo-xazoles and 2-aminobenzothiazoles catalyzed by Vitreoscilla hemoglobin incorporating a cobalt porphyrin cofactor, Green Chemistry, 2021,23, 8047-8052 (2021 Green Chemistry Hot Articles)
(15) Fengxi Li, Chunyu Wang, Yaning Xu, Zixian Zhao, Jiali Su, Chenhan Luo, Yujie Ning, Zhengqiang Li, Chen Li, Lei Wang, Efficient synthesis of unsymmetrical trisubstituted 1,3,5-triazines catalyzed by hemoglobin, Molecular Catalysis, 505 (2021) 111519.
(16) Jiaxu Liu, Wenxin Zhao, Liu Zhang, Min Zhang, Yanqiang Chen, You Xu, Yinghua Li*, Lei Wang*, Synthesis of substituted 2H-chromenes catalyzed by lipase immobilized on magnetic multiwalled carbon nanotubes, Biotechnology Applied Biochemistry, 2021, 68(2), 411-416.
(17) Fengxi Li, Yaning Xu, Ciduo Wang, Chunyu Wang, Ruihong Zhao* and Lei Wang*, Efficient Synthesis of Cyano-containing Multi-substituted Indoles Catalyzed by Lipase, Bioorganic Chemistry, 2021, 107, 104583
(18) Fengxi Li, Jiali Su, Yaning Xu, Jiaxu Liu, Yue Yu, Chunyu Wang, Zhengqiang Li, Chen Li* and Lei Wang*, A glucoseoxidase-hemoglobin system for efficient oxysulfonylation of alkenes/alkynes in water, Molecular catalysis, 500 (2021) 111336
(19) Jiaxu Liu, Fengxi Li, Xin Zheng, Jiali Su, Yue Yu, Lei Wang*, Hong Zhuang*, Lipase-catalyzed synthesis of polyhydroxyalkyl furans from unprotected sugars and malononitrile, Process Biochemistry, Process Biochemitry, 2021, 101, 99-103.
(20) Fengxi Li, Xuyong Tang, Yaning Xu, Chunyu Wang, Zhi Wang, Zhengqiang Li*, Lei Wang*, An efficient dual-protein cascade reaction for the synthesis of quinoxalines, Org. Lett., 2020, 22(10), 3900-3904.
