师资队伍

细胞生物学与生物物理学系

金英花

日期:2020-08-11 点击数: 来源:

      名:

金英花

      称:

教授、唐敖庆领军学者

最高学位:

博士

    话:

0431-85155221

      件:

yhjin@jlu.edu.cn

工作地点:

新葡的京集团8814生命科学楼277

研究方向

1. 恶性肿瘤精准治疗靶点的研究

2. 人参作用机制的研究与人参产品的开发

 3. 抗肿瘤中药新药的研发

教育经历

1983年-1988年:新葡的京集团8814分子生物系,理学学士

1994年-1996年: 国立首尔大学药学院,药学硕士

1996年-2000年: 国立首尔大学药学院,药学博士

工作经历

2000年-2002年:国立首尔大学综合药物研究所博士后

2002年-2004年:国立首尔大学综合药物研究所资深研究员

2004年-今:新葡的京集团8814教授、博士生导师

2014年-2014年:美国范德堡大学医学院,高级研究学者

 2011年-今:中国细胞生物学学会,理事、常务理事

荣誉称号

2018年中国侨界特殊贡献奖

2018年长白慧谷海外高端领军人才

2019年延边金达莱学者

2021年第一批长白山人才工程“长白山领军团队负责人”

研究成果

1. 揭示了细胞增殖周期G1/S 期的关键驱动激酶Cdk2 对细胞凋亡的促进作用,阐明了哺乳动物细胞精确平衡细胞增殖和细胞死亡的分子机制,是细胞凋亡通路的重要补充。
2. 系统筛选了稀有人参皂苷的人类靶点,为人参抗肿瘤作用提供了依据。
3.   在人参深加工领域取得了重大进展。利用生物转化技术对吉林人参进行深加工,制备了《百年参素》系列人参深加工产品。《百年参素》中高活性稀有人参皂苷群含量达到皂苷总量的60%,这是未经加工吉林人参的500倍。同时,彻底解决了人参“上火、升血压”等副作用,任何体质的人群均可享用、获益。
4. 负责完成了6项国家自然科学基金项目,负责执行7项省部级项目,在Protein Cell, JBC, EMBO Rep等国际重点杂志上发表SCI论文70篇,被引次数达2000余次,授权专利7项。


发表的部分论文

1.     Chen Chen, Yu-Shi Wang, En-Ting Zhang, Gang-Ao Li, Wen-Yuan Liu,  Yang Li, and Ying-Hua Jin * (20S) Ginsenoside Rh2 exerts its anti‐tumor  effect by disrupting the HSP90A‐Cdc37 system in human liver cancer  cells,Int. J. Mol. Sci. 2021, 22, 13170,
2.    Yu-Shi Wang, Chen  Chen, Shi-Yin Zhang, Yang Li and Ying-Hua Jin * (20S) Ginsenoside Rh2  Inhibits STAT3/VEGF Signaling by Targeting Annexin A2,Int. J. Mol. Sci.  2021, 22, 9289
3.    Wang YS, Li H, Li Y, Zhang S, Jin YH*,  (20S)G-Rh2 inhibits NF-Kappa B regulated epithelial-mesenchymal  transition by targeting Annexin A2. Biomolecules, 2020, 10, 528
4.     Li H, Chen C, Li Y, Jin YH*, Specific interaction with human serum  albumin reduces ginsenoside cytotoxicity in human umbilical vein  endothelial cells, Frontiers in Pharmacology, doi.org/10.3389/  fphar.2020.00498
5.    Yu-Shi Wang, Hongyan Zhu, He Li, Bing Zhao,  Ying-Hua Jin*. Ginsenoside compound K inhibits NF-κB by targeting  Annexin A2. J Ginseng Res, 2019,43,452-459
6.    Yu-Shi Wang, He Li,  Hongyan Zhu, Yang Li, Ying-Hua Jin* Identification of natural compounds  targeting Annexin A2 with an anti-cancer effect  Protein Cell, 2018,  9(6):568–579
7.    Yu-Shi Wang, Yingjia Lin, He Li, Yang Li,  Zhiguang Song,Ying-Hua Jin*  The identification of molecular target of  (20S) ginsenoside Rh2 for its anti-cancer activity Scientific Reports 7,  12408 (2017) doi:10.1038/s41598-017-12572-4
8.    Yingjia Lin, Yang  Li, Zhi-Guang Song, Hongyan Zhu, Ying-Hua Jin* The interaction of serum  albumin with ginsenoside Rh2 (G-Rh2) resulted in the downregulation of  G-Rh2 cytotoxicity J Ginseng Res 2017,41,330-338
9.    Yuan Shen,  Shanshan Liu, Jiao Fan, Yinghua Jin,* , Baolei Tian, Xiaofei Zheng*,  Hanjiang Fu*, Nuclear retention of the lncRNA SNHG1 by doxorubicin  attenuates hnRNPC–p53 protein interactions EMBO Rep. 2017,18(4),536-548   (IF:8.807, 被引6次)
10.    Yang Li,Xiaokang Liu,Dan Jiang, Yingjia  Lin,Yushi Wang,Qing Li,Ying-Hua Jin* Betulin induces reactive oxygen  species-dependent apoptosis in human gastric cancer SGC7901 cells Arch.  Pharm. Res.  2016,39(9),1257-1265, 2016. 09
11.    Shanshan Liu,  Juanjuan Zhu, Taifeng Jiang, Yiran Zhong, Yi Tie,Yongge Wu, Xiaofei  Zheng Yinghua Jin* & Hanjiang Fu* Identification of lncRNA MEG3  Binding Protein Using MS2-Tagged RNA Affinity Purification and Mass  Spectrometry,Appl Biochem Biotechnol  2015, 176, 1834-1845
12.     Yingjia Lin,Dan Jiang,Yang Li,Xinye Han,Di Yu,Jeong Hill Park,Ying-Hua  Jin* Effect of sun ginseng potentiation on epirubicin and  paclitaxel-induced apoptosis in human cervical cancer cells J Ginseng  Res 2015,39,22-28 (IF:6.06, 被引93次)
13.    Chun-Ying Liu, Rui-Xin  Zhou, Chang-Kai Sun, Ying-Hua Jin, Hong-Shan Yu, Tian-Yang Zhang,  Long-Quan Xu, Feng-Xie Jin. Preparation of minor ginsenosides C-Mc, C-Y,  F2, and C-K fromAmerican ginseng PPD-ginsenoside using special  ginsenosidase type-I from Aspergillus niger g.848. J Ginseng Res, 2015,  39:221-229
14.    Xiao-Xi Guo, Yang Li, Chao Sun, Dan Jiang, Ying-Hua  Jin* p53-dependent Fas expression is critical for Ginsenoside Rh2  triggered caspase-8 activation in HeLa cells. Protein Cell 2014, 5, 224 –  234 (IF:14.87,被引53次)
15.    Liu CY, Jin YH,Yu HS, Sun CK, Zhou SP,  Zhu YH, Xu LQ, Yu C, Jin FX. Preparation of przewalskinic acid A from  salvianolic acid B using a crude enzyme from an Aspergillus oryzae  strain. J Ind Microbiol Biotechnol, 2014, 41, 887-892.
16.    Liu CY,  Jin YH, Yu HS, Sun CK, Gao P, Xiao YK, Zhang TY, Xu LQ, Im WT, Jin FX.  Biotransformation pathway and kinetics of ginsenosidase type I  hydrolyzing 3-O- and 20-O-multi- glucosides of PPD type ginsenosides.  Process Biochem, 2014, 49, 813-820.
17.    Chao Sun, Xiaoxi Guo,  Ying-Hua Jin* Apoptosis is Induced in Cancer Cells via the Mitochondrial  Pathway by the Novel Xylocydine-Derived Compound JRS-15. Int. J. Mol.  Sci. 2013, 14, 850-870
18.    Xiaoxi Guo, Qiao Guo, Yang Li, Seung ki  Lee*, Ying-Hua Jin*, Ginsenoside Rh2 induces human hepatoma cell  apoptosis via Bax/Bak triggered cytochrome c release and  caspase-9/-caspase-8 activation. Int. J. Mol. Sci. 2012, 13, 15523-15535  (被引47次)
19.    Ying Liu, Guo-Yan Zhang, Yang Li, Ya-Nan Zhang,  Sheng-Ji An*, Ying-Hua Jin* Synthesis of Novel Amide Derivatives with In  Vitro Antiproliferative and Cytotoxic Activity Heteroatom Chemistry  2013, 24, 9-17
20.    Zhuo Zhan, Kan He, Yang Li, Ying-Hua Jin*  Phosphorylation of Rad9 at Serine 328 by Cyclin A-Cdk2 Triggers  Apoptosis via Interfering Bcl-xL. PLoS One. 2012, 7 (9) e44923.(被引 9次)
21.     Chuan Xiao§, Chao Sun§, Weiwei Han, Feng Pan, Yu Li, Zhi-Guang  Song, Ying-Hua Jin Synthesis of 6-(het) ary Xylocydine Analogues and  Evaluating their Inhibitory Activities of CDK1 and CDK2 in Vitro. Bioorg  & Medi Chem. 2011,19, 7100-7110
22.    Xiaoxi Guo, Hanna Kim,  Yang Li, Hyungshin Yim, Seung Ki Lee*, Ying-Hua Jin. Cdk2 acts upstream  of mitochondrial permeability transition during paclitaxel-induced  apoptosis. Protein & Cell. 2011, 2, 543-553. (IF:14.87, 被引6次)
23.     Qing Li, Yang Li, Xiaoyu Wang, Xuexun Fang, Kan He, Xiaoxi Guo, Zhuo  Zhan, Chao Sun, and Ying-Hua Jin*, Cotreatment with ginsenoside Rh2 and  betulinic acid synergistically induces apoptosis in human cancer cells  in association with enhanced capsase-8 activation, Bax translocation,  and cytochrome c release.  Mol Carcinogen 2011, 50,760-769  (IF:4.856,被引71次)
24.    Yang Li , Kan He, Yinghui Huang, Daxin Zheng,  Chang Gao, Lin Cui, and Ying-Hua Jin*, Betulin induces mitochondrial  cytochrome c release associated apoptosis in human cancer cells.  Mol  Carcinogen 2010, 49, 630-640. (IF:4.856, 被引120次)